AbbVie’s Mavyret Cures Hep C at High Rates in Real-World Analysis

Using an actual testing of AbbVie’s Mavyret with drugs (glecaprevir/pibrentasvir) found (HCV) treatment was a highly great find as well as tolerated well so MedPage Today reports.

Longitudinal study

Researchers conducted a reviewing longitudinal study of those patients with HVC starting Mavyret at 30 Italy clinics. This study watched an old-style gage of the person having been cured of HVC and has an unremitting virologic response for 12 weeks after completing the therapy (SVR12), and the quantity of those who had achieved 4 weeks upon finishing therapy (SVR4). Anyone with an SVR4 has an outstanding chance of keeping an undetectable HVC load for another 8 weeks and then achieving an SVR12.


The findings were announced at the “52nd International Liver Congress” held in Paris. Between Oct. 2017 and Jan. 2018, 723 patients treated using Mavyret, 639 for 8 weeks and 84 for 12 -16 weeks. About 90{fb9a4be0d6494174e6be9660e119e25a878ea9b5c7f2169440a84f81fc131373} of those treated for 8 weeks had mild or no fibrosis.

Completed treatment

Of 347 patients who finished the treatment and had made it to the 4-week post-treatment mark, 46 or 99.7{fb9a4be0d6494174e6be9660e119e25a878ea9b5c7f2169440a84f81fc131373} has to reach SVR4. And for the 49 patients who had made it to the 12-week post-treatment mark, 48 or 98{fb9a4be0d6494174e6be9660e119e25a878ea9b5c7f2169440a84f81fc131373} had received SVR12. The corresponding rates were 99.7{fb9a4be0d6494174e6be9660e119e25a878ea9b5c7f2169440a84f81fc131373} and 97.7{fb9a4be0d6494174e6be9660e119e25a878ea9b5c7f2169440a84f81fc131373} among those treated for 8 weeks and 100{fb9a4be0d6494174e6be9660e119e25a878ea9b5c7f2169440a84f81fc131373} of those treated for 12 -16 weeks. One patient in the 8-week treatment did have a viral deterioration.

Of all who received Mavyret, 6{fb9a4be0d6494174e6be9660e119e25a878ea9b5c7f2169440a84f81fc131373} treated for an 8-week group and 13{fb9a4be0d6494174e6be9660e119e25a878ea9b5c7f2169440a84f81fc131373} treated 12- to 16-week group experienced conflicting health problems. A respective 1 and 3 patients in each group experienced adverse health problems that led them to stop this treatment. One patient died in the shorter group for treatment and 2 people died in a longer treatment group.

FDA approved

The Food and Drug Administration or FDA approved recently AbbVie’s Mavyret, the newest treatment on the market for chronic hepatitis C virus infection for those people without cirrhosis or with compensated cirrhosis. Mavyret which is glecaprevir 100 mg and pibrentasvir 40 mg is taking daily – 3 tablets for a total daily dose of 300 mg glecaprevir and 120 mg pibrentasvir, to treat genotypes 1 through 6.

Need to know about Mavyret

AbbVie’s Mavyret is one pill comprising two drugs. Both drugs are direct-acting antivirals (DAAs) which mean they directly inhibit hepatitis C virus replication. The US FDA approved Mavyret for (HCV) infection across all major genotypes (GT 1-6). Mavyret is an 8-week, pan-genotypic treatment for those patients without cirrhosis and who are new to treatment. 95{fb9a4be0d6494174e6be9660e119e25a878ea9b5c7f2169440a84f81fc131373} of US patients with HCV patients may be qualified for Mavyret treatment and this includes patients with compensated cirrhosis or without cirrhosis as well as those with limited choices of treatment, such as patients having chronic kidney disease (CKD).

New Development

This is the most promising new drug for HCV and should do well in the future of these patients.

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