Daily Archives: February 8, 2019

Spiriva Respimat in the Treatment of COPD

Tiotropium bromide is a specific anticholinergic with a long-lasting effect that has an affinity for the M1-M5 subtypes of muscarinic receptors. Competitively and reversibly blocking receptors of the M3 subtype in the airways leads to relaxation of the smooth muscles of the bronchi. In vitro and in vivo studies, the bronchodilating effect was dose-dependent and lasted more than 24 hours. ...

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